Vitamin A

• Limit initial use to three times per week, applying two to three drops, only in the evening after cleansing. Gradually increase the frequency of application to every night.
• If using a water-based serum, this would be applied before the 0.5% Retinol.

• Combination
• Oily

• Sun damage
• Fine lines / wrinkles
• Dullness / poor complexion
• Loss of firmness / elasticity

Alpha Hydroxy Acids, Beta Hydroxy Acids, Polyhydroxy Acids

• Avoid layering with direct acids to avoid over stimulation of the skin and impairing the barrier.

• Patch test before use.
• Keep away from children.
• Store at room temperature.
• Do not use on broken skin.
• Use sunscreen every morning.
• If irritation occurs, stop use. If problem persists, see a doctor.
• Avoid contact with eyes.
• Not suitable for someone with a mushroom allergy.
• Not suitable for use during pregnancy or breastfeeding.

1. Kong R, Cui Y, Fisher GJ, Wang X, Cehn Y, Schneider LM, Maimudar G. A comparative study of the effects of retinol and retinoic acid on histological, molecular and clinical properties of human skin. J Cosmet Dermatol 2016; 49-57.
2. Zaenglein AL. Topical retinoids in the treatment of acne vulgaris. Dept of Dermatol Paed 2008; 27(3):177-82.
3. Chien A. Retinoids in Acne Management: Review of Current Understanding, Future Considerations, and Focus on Topical Treatments. J Drugs Dermatol 2018; 17(12):51-55.
4. Fisher GJ, Voorhees JJ. Molecular mechanisms of photaging and its prevention by retinoic acid: ultraviolet irrigation induces MAP kinase signal transduction cascades that induce AP-1 regulated matrix metallproteinases that degrade human skin in vivo. J Investig Dermatol Symp Proc 1998; 3(1):61-68.
5. Rona C, Vailati F, Berardesca E. The cosmetic treatment of wrinkles. J Cosmet Dermatol. 2004; 3(1):26-34.

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